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Cost considerations for systemic therapy for patients with advanced genitourinary malignancies
Mark A Henry1, Andrew Leung1, Christopher P Filson1
1Department of Urology, Emory University School of Medicine, Atlanta, Georgia.
Cancer
|March 27, 2018
Summary
The rising cost of cancer care, particularly for novel systemic therapies in urologic malignancies, lacks a standard measure for cost-effectiveness. Defining the appropriate cost per added year of life remains controversial.
Area of Science:
- Oncology
- Health Economics
- Urologic Oncology
Background:
- Rising healthcare costs in the US are a significant concern, with cancer care being a major contributor.
- Assessing the cost-effectiveness of cancer therapies is complex, lacking standardized metrics.
- Debate exists regarding the appropriate cost per life-year gained from medical interventions.
Purpose of the Study:
- To review the cost, effectiveness, and comparative cost-effectiveness of novel systemic therapies for urologic malignancies.
- To explore the challenges in defining and measuring cost-effectiveness in cancer care.
- To contribute to the discussion on value in cancer treatment.
Main Methods:
- Literature review of novel systemic therapies for urologic cancers.
- Analysis of cost-effectiveness data and methodologies.
- Examination of comparative effectiveness studies.
Main Results:
- Novel systemic therapies for urologic cancers vary significantly in cost and demonstrated effectiveness.
- There is no universal agreement on the acceptable cost per quality-adjusted life-year (QALY) gained.
- Comparative cost-effectiveness analyses reveal differing value propositions for various treatments.
Conclusions:
- The evaluation of novel systemic therapies for urologic malignancies requires careful consideration of both cost and clinical benefit.
- Standardized metrics for cost-effectiveness are needed to guide clinical and policy decisions.
- Balancing innovation in cancer treatment with affordability is a critical challenge for healthcare systems.
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