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Updated: Feb 12, 2026

Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts
Published on: October 25, 2011
A Fibroblast Is Not a Fibroblast Is Not a Fibroblast
Michael S Hu1, Alessandra L Moore1, Michael T Longaker2
1Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, California, USA.
Abstract:
Fibrosis after injury is a huge public health concern, leading to morbidity, mortality, and expenditure of billions of health care dollars. Recent mouse studies have shown that dermal fibroblasts are heterogeneous. New research using single-cell RNA sequencing to identify major fibroblast populations in humans is paving the way to a better understanding of fibroblast heterogeneity and fibrosis.
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