Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026

Same author

Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the Drosophila optic lobe.

Nature neuroscience·2026

Same author

Retinal calcium waves coordinate uniform tissue patterning of the <i>Drosophila</i> eye.

Science (New York, N.Y.)·2025

Same author

Transcriptional interferences ensure one olfactory receptor per ant neuron.

Nature·2025

Same author

RNA-RNA interactions coordinate GABA metabolism and signaling.

bioRxiv : the preprint server for biology·2025

Same author

Retinal Calcium Waves Coordinate Uniform Tissue Patterning of the <i>Drosophila</i> Eye.

bioRxiv : the preprint server for biology·2025

Same journal

SqueakPose Studio, an end-to-end platform for pose estimation and real-time edge-AI deployment.

eLife·2026

Same journal

Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival.

eLife·2026

Same journal

Activity-dependent CO<sub>2</sub> production in the axon triggers opening of Connexin32 in the Schwann cell paranode.

eLife·2026

Same journal

Lipid packing contributes to the confinement of caveolae to the plasma membrane.

eLife·2026

Same journal

A coma pattern-based autofocusing method resolves bacterial cold shock response at single-cell level.

eLife·2026

Same journal

Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy.

eLife·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 12, 2026

Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses

Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses

Published on: November 24, 2014

Cherub versus brat.

Jennifer A Malin¹, Claude Desplan¹

¹Department of Biology, New York University, New York, United States.

|March 28, 2018

Summary

This summary is machine-generated.

The long non-coding RNA molecule, cherub, drives tumor development. This discovery offers new insights into cancer progression and potential therapeutic targets.

Keywords:

D. melanogaster brat cancer biology cherub developmental biology lncRNA neural stem cells neuroblasts stem cells tumorigenesis

More Related Videos

In Vivo Forward Genetic Screen to Identify Novel Neuroprotective Genes in Drosophila melanogaster

In Vivo Forward Genetic Screen to Identify Novel Neuroprotective Genes in Drosophila melanogaster

Published on: July 11, 2019

Nasal Potential Difference to Quantify Trans-epithelial Ion Transport in Mice

Nasal Potential Difference to Quantify Trans-epithelial Ion Transport in Mice

Published on: July 4, 2018

Related Experiment Videos

Last Updated: Feb 12, 2026

Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses

Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses

Published on: November 24, 2014

In Vivo Forward Genetic Screen to Identify Novel Neuroprotective Genes in Drosophila melanogaster

In Vivo Forward Genetic Screen to Identify Novel Neuroprotective Genes in Drosophila melanogaster

Published on: July 11, 2019

Nasal Potential Difference to Quantify Trans-epithelial Ion Transport in Mice

Nasal Potential Difference to Quantify Trans-epithelial Ion Transport in Mice

Published on: July 4, 2018

Area of Science:

Molecular Biology
Oncology

Background:

Long non-coding RNAs (lncRNAs) play crucial roles in gene regulation.
Aberrant lncRNA expression is implicated in various human diseases, including cancer.

Purpose of the Study:

To investigate the role of the lncRNA molecule, cherub, in tumor development.
To identify cherub as a potential driver of oncogenesis.

Main Methods:

Analysis of cherub expression levels in tumor tissues.
Functional studies using cell lines and animal models to assess cherub's impact on tumor growth.

Main Results:

Cherub expression is significantly upregulated in tumors.
Overexpression of cherub promotes tumor cell proliferation and migration.
Knockdown of cherub inhibits tumor growth.

Conclusions:

The lncRNA cherub acts as a driver of tumor development.
Cherub represents a potential therapeutic target for cancer treatment.