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Synthesis of chitosan-based micelles for pH responsive drug release and antibacterial application

Hao Chen1, Zi Ye2, Lin Sun2

  • 1School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China; Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, 32500, China.

Carbohydrate Polymers
|March 28, 2018
PubMed

Insights

New hybrid multilayer films offer controlled release of triclosan (TCA), combating drug-resistant bacteria. These films demonstrate high sterilization efficiency and biocompatibility, providing a promising solution for bacterial infections.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Antimicrobial Research

Background:

  • Inefficient antibiotic release from conventional systems accelerates the development of drug-resistant bacteria.
  • There is a need for advanced drug delivery systems that ensure controlled and effective release of antimicrobial agents.

Purpose of the Study:

  • To construct methoxy poly(ethylene glycol)-poly(ε-caprolactone)-chitosan/montmorillonite (MPC/MMT) hybrid multilayer films.
  • To investigate the pH-dependent release of triclosan (TCA) from these films for treating bacterial infections.
  • To evaluate the antibacterial efficacy and biocompatibility of the developed multilayer films.

Main Methods:

  • Fabrication of (MPC-T/MMT)10 hybrid multilayer films with a thickness of 384.4 ± 26.5 nm and TCA loading of 2.4 μg/cm2.
  • Antibacterial testing against Staphylococcus aureus, Escherichia coli, and Staphylococcus epidermidis using shake-flask assays, zone of inhibition, and live/dead staining.
  • Assessment of pH-responsive TCA release by measuring bactericidal activity in phosphate-buffered saline (PBS, pH 7.4) and MES buffer (pH 5.5).

Main Results:

  • The multilayer films exhibited high sterilization efficiency against tested bacterial strains.
  • pH-responsive release of TCA was observed, with enhanced activity at lower pH (MES, pH 5.5).
  • Cell biocompatibility tests on L929 fibroblasts and human lens epithelial cells showed no adverse effects.

Conclusions:

  • The developed MPC/MMT hybrid multilayer films provide an effective platform for controlled, pH-responsive release of triclosan.
  • These films demonstrate significant potential for treating bacterial infections while maintaining good biocompatibility.
  • The study highlights a promising strategy to mitigate the challenge of antibiotic resistance through advanced material design.
Keywords:
Bacterial infectionDrug deliveryMicellesMultilayer films

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