Related Experiment Video

Updated: Feb 12, 2026

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.0K

Relation of Testosterone Levels to Mortality in Men With Heart Failure

Akiomi Yoshihisa1, Satoshi Suzuki1, Yu Sato1

  • 1Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.

The American Journal of Cardiology
|March 28, 2018
PubMed

Insights

Low testosterone levels in men with heart failure are linked to increased mortality, reduced exercise capacity, and myocardial damage. This study highlights testosterone

Area of Science:

  • Cardiology
  • Endocrinology
  • Internal Medicine

Background:

  • Heart failure (HF) is a complex syndrome with significant morbidity and mortality.
  • The role of hormonal imbalances, particularly testosterone deficiency, in HF prognosis is an area of ongoing research.
  • Understanding the relationship between testosterone levels and cardiac function, damage, and exercise capacity is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the impact of serum total testosterone (TT) levels on the prognosis of heart failure (HF) in men.
  • To examine the association between TT levels and underlying cardiac function, myocardial damage, and exercise capacity in HF patients.
  • To identify TT as a potential independent predictor of all-cause mortality in men with HF.

Main Methods:

  • Analysis of 618 male HF patients, stratified into four quartiles based on serum total testosterone (TT) levels.
  • Kaplan-Meier survival analysis and multivariable Cox proportional hazard analysis to assess all-cause mortality.
  • Comparison of echocardiography parameters, cardiopulmonary exercise testing (peak VO2), B-type natriuretic peptide, and cardiac troponin I levels across TT quartiles.

Main Results:

  • All-cause mortality progressively increased from the highest to the lowest TT quartile.
  • Low serum TT (fourth quartile) was associated with significantly higher levels of cardiac troponin I (myocardial damage) and lower peak VO2 (exercise capacity) compared to the highest TT quartile.
  • Total testosterone (TT) was identified as an independent predictor of all-cause mortality in men with HF (HR 0.929, p=0.042).

Conclusions:

  • Decreased serum testosterone levels are significantly associated with adverse outcomes in men with heart failure.
  • Lower testosterone is linked to increased myocardial damage and reduced exercise capacity, contributing to higher mortality.
  • Serum testosterone levels may serve as a valuable prognostic marker in male patients with HF.

More Related Videos

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

6.9K
Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients03:47

Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients

Published on: July 12, 2024

1.2K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.0K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.0K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
951
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
395
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.0K
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
360