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Gut microbiota profiles in treatment-naïve children with attention deficit hyperactivity disorder

Hai-Yin Jiang1, Yuan-Yue Zhou2, Guo-Ling Zhou2

  • 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.

Behavioural Brain Research
|March 28, 2018
PubMed

Insights

Children with attention-deficit/hyperactivity disorder (ADHD) show reduced levels of the gut bacterium Faecalibacterium. Lower Faecalibacterium abundance correlates with increased ADHD symptom severity in children.

Area of Science:

  • Neuroscience
  • Microbiology
  • Genetics

Background:

  • Emerging evidence links gut microbiota to neurodevelopment.
  • The specific gut microbiota composition in children with attention-deficit/hyperactivity disorder (ADHD) is not well understood.

Purpose of the Study:

  • To characterize gut microbiota in treatment-naive children with ADHD.
  • To explore the relationship between gut microbiota and ADHD symptom severity.

Main Methods:

  • High-throughput pyrosequencing analyzed fecal microbiota from 51 children with ADHD and 32 healthy controls.
  • Operational taxonomical unit (OTU)-level analysis was performed.

Main Results:

  • Children with ADHD exhibited significantly lower levels of Faecalibacterium compared to healthy controls.
  • Faecalibacterium abundance negatively correlated with ADHD symptom severity.
  • No significant differences in alpha diversity were observed between groups.

Conclusions:

  • Gut microbiota alterations may be involved in psychiatric disorders like ADHD.
  • Faecalibacterium could serve as a potential biomarker for gut microbiota in ADHD.
  • Further research is required to confirm findings and understand causal relationships.
Abstract

Keywords:
Gut-brain axisHyperactivityInattentionMicrobiome

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