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A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
Published on: December 26, 2015
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Neurovascular Coupling During Visual Stimulation in Multiple Sclerosis: A MEG-fMRI Study.
Rachael Stickland1, Marek Allen1, Lorenzo Magazzini1
1Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University School of Psychology, Maindy Road, Cardiff CF24 4HQ, UK.
Neuroscience
|March 28, 2018
Summary
Neurovascular coupling, the link between brain activity and blood flow, appears preserved in Multiple Sclerosis (MS) patients despite reduced neuronal and vascular responses. This suggests MS alters brain function and blood flow independently.
Area of Science:
- Neuroscience
- Cerebrovascular Medicine
- Medical Imaging
Background:
- Neurovascular coupling links neuronal activity to cerebral blood flow.
- Potential impairment in Multiple Sclerosis (MS) is linked to hypoperfusion, altered reactivity, and vasoactive compounds.
Purpose of the Study:
- To test the hypothesis that neurovascular coupling is impaired in MS.
- To characterize the relationship between gamma band oscillations (MEG) and hemodynamic responses (fMRI) in MS patients.
Main Methods:
- Compared neurovascular coupling in 13 MS patients and 10 controls using visual stimuli.
- Measured neuronal activity via magnetoencephalography (MEG) and hemodynamic response using functional MRI (fMRI).
- Assessed visual acuity, P100 latencies, gray matter volume, and baseline cerebral blood flow (CBF).
Main Results:
- MS patients showed reduced peak gamma power, BOLD, and CBF responses.
- No significant group differences in visual acuity, P100 latencies, gray matter volume, or baseline CBF.
- Neurovascular coupling was not significantly different between MS patients and controls.
Conclusions:
- Neuronal and vascular responses are altered in MS patients.
- Reduced gamma power may indicate gray matter dysfunction.
- Neurovascular coupling appears preserved in MS, despite individual neuronal and vascular alterations.
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