Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

7.7K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.7K
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

1
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
1
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

3
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
3
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

2
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
2
Cross-reactivity00:42

Cross-reactivity

33.1K
Overview
33.1K
Reactivity of Enols01:18

Reactivity of Enols

4.2K
Enols are a class of compounds where a hydroxyl group is attached to a carbon–carbon double bond, which implies that it is a vinyl alcohol. A carbonyl compound with an α hydrogen undergoes keto–enol tautomerism and remains in equilibrium with its tautomer, the enol form. Usually, the keto tautomer is present in a higher concentration than the enol tautomer due to the higher bond energy of C=O compared to C=C. Moreover, the direction of the keto–enol equilibrium is...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dexamethasone-loaded nanoparticles promote angiogenesis and pro-regenerative macrophages polarization in the presence of titanium debris: a rabbit critical defect model.

Journal of dentistry·2026
Same author

Effect of parathyroid hormone doped nanoparticles on multiscale modeling and hydroxyapatite formation at the resin-dentin interface.

Dental materials : official publication of the Academy of Dental Materials·2026
Same author

Examining the influence of parathyroid hormone-doped nanoparticles on resin-dentin interface strength and composition.

Journal of dentistry·2026
Same author

Polymeric nanoparticles functionalized with dexamethasone attenuate the osteogenic inhibition induced by titanium debris.

Dental materials : official publication of the Academy of Dental Materials·2025
Same author

Bio-Membrane-Based Nanofiber Scaffolds: Targeted and Controlled Carriers for Drug Delivery-An Experimental In Vivo Study.

Biomimetics (Basel, Switzerland)·2025
Same author

Association of Preoperative Cardiac Magnetic Resonance and Echocardiography with Postoperative Left Ventricular Dysfunction in Primary Mitral Regurgitation.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2025

Related Experiment Video

Updated: Feb 12, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

11.9K

Improved reactive nanoparticles to treat dentin hypersensitivity.

Manuel Toledano-Osorio1, Estrella Osorio1, Fátima S Aguilera1

  • 1University of Granada, Faculty of Dentistry, Dental Materials Section, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain.

Acta Biomaterialia
|March 28, 2018
PubMed
Summary

Zinc-based nanoparticles effectively occluded dentinal tubules and reduced fluid flow, promoting dentin remineralization and enhancing mechanical properties. Calcium-based nanoparticles also showed significant occlusion and fluid flow reduction.

Keywords:
Cervical dentinDMAHypersensitivityNanoparticles

More Related Videos

Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles
09:46

Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles

Published on: August 26, 2018

9.5K
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.7K

Related Experiment Videos

Last Updated: Feb 12, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

11.9K
Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles
09:46

Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles

Published on: August 26, 2018

9.5K
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.7K

Area of Science:

  • Biomaterials Science
  • Nanotechnology in Dentistry
  • Dental Materials

Background:

  • Dentin hypersensitivity (DH) is often caused by acid erosion, leading to open dentinal tubules and demineralization.
  • Nanoparticle-based solutions offer potential for dentin remineralization and tubule occlusion to manage DH.

Purpose of the Study:

  • To evaluate nanoparticle solutions for reducing dentin permeability.
  • To assess the viscoelastic performance of cervical dentin after nanoparticle application.
  • To investigate the efficacy of zinc, calcium, and doxycycline-loaded nanoparticles.

Main Methods:

  • Application of four experimental nanoparticle solutions (zinc, calcium, doxycycline-loaded polymeric NPs) on citric acid-etched dentin.
  • Evaluation of fluid filtration, tubule occlusion, and viscoelastic properties (complex, storage, loss modulus, tan delta) after 24h and 7d storage.
  • Microscopy (Field Emission Scanning Electron Microscopy), Energy Dispersive Analysis, Atomic Force Microscopy (AFM), and Nano-DMA analysis were employed.

Main Results:

  • Zinc-loaded and calcium-loaded nanoparticles achieved 100% tubule occlusion after 7 days.
  • Doxycycline-loaded nanoparticles were ineffective in tubule occlusion and fluid flow reduction.
  • Zinc-nanoparticles demonstrated higher complex modulus values, suggesting enhanced dentin remodeling and mechanical properties.

Conclusions:

  • Zinc-based nanoparticles are effective for dentin remineralization and tubular occlusion.
  • Calcium-based nanoparticles also show promise in reducing dentinal fluid flow.
  • Further clinical studies are encouraged to validate the benefits of zinc-doped nanoparticles for dentin hypersensitivity.