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Neurotoxicity of quinolinate in the rat nucleus basalis magnocellularis
R J Boegman1, R Metcalf, R J Riopelle
1Department of Pharmacology and Toxicology, Queen's University, Kingston, Ont., Canada.
Brain Research
|August 11, 1987
Abstract:
Injections of quinolinic acid (QUIN) alone or combinations of QUIN with dipicolinic acid, Mg2+ or 3,4-diaminopyridine were made into the nucleus basalis magnocellularis of the rat. Choline acetyltransferase activity in the cortex decreased following injections of QUIN and this was antagonized by co-injections of QUIN with dipicolinic acid or Mg2+. Co-injections of QUIN with 3,4-diaminopyridine increased the neurotoxicity of quinolinic acid, while diaminopyridine alone was not toxic.