Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Ferritin selectively suppresses delayed-type hypersensitivity responses at induction or effector phase.

T Harada¹, M Baba, I Torii

¹Department of Pathology, Shimane Medical University, Izumo, Japan.

Cellular Immunology

|October 1, 1987

Summary

Ferritin selectively suppresses cell-mediated immunity, specifically delayed-type hypersensitivity (DTH), by affecting antigen presentation. It does not inhibit antibody-mediated responses like the Arthus reaction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Modulation of IgD and CD20 by ligation of CD5 on tonsillar B cells.

Scandinavian journal of immunology·2002

Same author

Differential endocytotic characteristics of a novel human B/DC cell line HBM-Noda: effective macropinocytic and phagocytic function rather than scavenging function.

Immunology·2001

Same author

A human B-lineage dendritic cell line, HBM-noda and its potential role in human T-cell leukemia/lymphoma virus type I infection.

Pathology international·2000

Same author

Constitutive expression of granulocyte-colony stimulating factor receptor on a human B-lymphoblastoid cell line.

British journal of haematology·1996

Same author

Superantigen toxic shock syndrome toxin-1 (TSST-1) enhances the replication of HIV-1 in peripheral blood mononuclear cells through selective activation of CD4+ T lymphocytes.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association·1995

Same author

Suppression by amiloride of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane.

International journal of cancer·1995

Area of Science:

Immunology
Cellular Immunity

Background:

Delayed-type hypersensitivity (DTH) and Arthus reactions are distinct immune responses.
Ferritin's immunomodulatory effects require further investigation.

Purpose of the Study:

To investigate the effect of ferritin on DTH and Arthus reactions.
To elucidate the mechanisms by which ferritin influences immune responses.

Main Methods:

Assessing DTH and Arthus reactions via footpad tests using various antigens.
Administering ferritin intraperitoneally at different time points relative to antigen exposure.
Evaluating primary antibody responses, including IgG and IgM plaque-forming cells (PFC).

Main Results:

Ferritin suppressed DTH induction or expression but not Arthus reactions.

Related Experiment Videos

Ferritin moderately decreased IgG PFC but not IgM PFC.

Ferritin's suppression was linked to antigen presentation and/or effector cell expansion in cell-mediated immunity.

Conclusions:

Ferritin selectively targets cell-mediated immunity, impacting antigen presentation or effector cell proliferation.
Ferritin may affect Ia-positive cells or lymphokine-responsive cells in DTH.
The study provides a model for differentiating T-cell-mediated from antibody-mediated inflammatory lesions.