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Endogenous atrial natriuretic factor in dogs with caval constriction
R H Freeman1, D Villarreal, R C Vari
1Department of Physiology, University of Missouri School of Medicine, Columbia 65212.
Circulation Research
|October 1, 1987
Summary
Constricting the inferior vena cava in dogs caused significant sodium retention and decreased atrial natriuretic factor (ANF) levels. This suggests reduced ANF may impair sodium excretion in this condition.
Area of Science:
- Cardiovascular Physiology
- Renal Physiology
- Endocrinology
Background:
- Chronic constriction of the thoracic inferior vena cava (IVC) leads to reduced cardiac filling pressure and output.
- This condition is associated with increased renin and aldosterone secretion, promoting sodium retention, ascites, and edema.
Purpose of the Study:
- To investigate the temporal changes in plasma immunoreactive atrial natriuretic factor (iANF) levels following chronic thoracic IVC constriction in conscious dogs.
Main Methods:
- Conscious dogs underwent chronic constriction of the thoracic IVC.
- Plasma iANF concentrations were measured at baseline and on days 2, 6, and 10 post-constriction.
- Plasma renin activity and aldosterone concentration were also monitored.
Main Results:
- All dogs exhibited avid sodium retention for at least 10 days post-constriction.
- Plasma renin activity and aldosterone concentration increased significantly (p < 0.05).
- Plasma iANF levels significantly decreased from baseline (70 ± 5 pg/ml) to 24 ± 7 pg/ml on day 2, 26 ± 10 pg/ml on day 6, and 34 ± 11 pg/ml on day 10 (p < 0.05).
Conclusions:
- Chronic sodium retention following thoracic IVC constriction is linked to sustained endocrine changes in renin-aldosterone and iANF.
- The study suggests that chronically decreased atrial natriuretic factor secretion may contribute to impaired sodium excretion in this IVC constriction model.