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Updated: Feb 12, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
Behaviour of the Foramen Ovale Flow in Fetuses with Intrauterine Growth Restriction
Ângela R L Nader1, Paulo Zielinsky1,2, Alexandre Antonio Naujorks1
1Unidade de Cardiologia Fetal, Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Background:
Foramen ovale (FO) flow may be altered in IUGR. This study was designed to test this hypothesis.
Methods:
Forty pregnant women (24-38 weeks) were divided into 3 groups: group I (IUGR), group II (adequate growth and maternal hypertension), and group III (normal controls). Impedance across the FO was assessed by the FO pulsatility index (FOPI): (systolic velocity - presystolic velocity)/mean velocity. Statistical analysis utilized ANOVA, Tukey test, and ROC curves.
Results:
Mean FOPI in IUGR fetuses (n = 15) was 3.70 ± 0.99 (3.15-4.26); in the group II (n = 12), it was 2.84 ± 0.69 (2.40-3.28), and in the group III (n = 13), it was 2.77 ± 0.44 (2.50-3.04) (p=0.004). FOPI and UtA RI were correlated (r = 0.375, p=0.017), as well as FOPI and UA RI (r = 0.356, p=0.024) and, inversely, FOPI and MCA RI (r = -0.359, p=0.023).
Conclusions:
The FO flow pulsatility index is increased in fetuses with IUGR, probably as a result of impaired left ventricular diastolic function.
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