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Updated: Feb 12, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
Tumor suppressor miR-211-5p is associated with cellular migration, proliferation and apoptosis in renal cell
Jing Quan1,2,3, Xiang Pan1,2,3, Tao He1,3
1Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Abstract:
Increasing evidence has demonstrated that microRNA (miRNA) serve an important role in the tumorigenesis of various types of cancer, such as renal cell carcinoma (RCC). The expression of miR-211-5p has been detected in RCC tissue by microarray profiling. However, studies regarding miR-211-5p and RCC remain rare. In the present study, the expression of miR-211-5p in RCC tissues and cell lines was revealed to be downregulated by reverse transcription-quantitative polymerase chain reaction analyses. The present results also revealed that the upregulation or downregulation of miR-211-5p inhibited or promoted, respectively, RCC cell proliferation, migration and invasion. In addition, the upregulation or downregulation of miR-211-5p induced or inhibited, respectively, RCC cell apoptosis. However, the present study only identified that downregulation of miR-211-5p promoted 786O and ACHN cell viability. The above results suggest that miR-211-5p may be a tumor suppressor in the tumorigenesis of RCC and may be a potential therapeutic target for RCC in the future. Further research should focus on the underlying mechanism of miR-211-5p in RCC and on investigating the possible use of miR-211-5p as a biomarker for RCC.
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