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In Vitro Assessment of Spray Deposition Patterns in a Pediatric (12 Year-Old) Nasal Cavity Model

Namita Sawant1, Maureen D Donovan2

  • 1Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, 115 S Grand Avenue, Iowa City, Iowa, 52242, USA.

Pharmaceutical Research
|March 28, 2018
PubMed

Insights

Pediatric nasal sprays deposit primarily in the front of the nose, potentially reducing drug effectiveness. This study evaluated nasal spray performance in children, finding limited drug delivery to key nasal regions.

Area of Science:

  • Pediatric Pharmacology
  • Drug Delivery Systems
  • Nasal Anatomy

Background:

  • Current nasal sprays use adult formulations for children.
  • Pediatric nasal airway dimensions differ significantly from adults.
  • The performance of pediatric nasal sprays requires specific evaluation.

Purpose of the Study:

  • To evaluate the deposition patterns of nasal sprays in children.
  • To compare pediatric nasal spray performance with adult standards.
  • To identify potential efficacy differences due to anatomical variations.

Main Methods:

  • Utilized a pediatric nasal cast derived from MRI scans of a 12-year-old.
  • Tested various nasal spray formulations with differing spray patterns.
  • Administered sprays into the cast under controlled laboratory conditions.

Main Results:

  • Nasal spray deposition was concentrated in the anterior nasal region in the pediatric cast.
  • Limited spray reached the critical turbinate region.
  • The primary absorptive and drug effect sites received minimal deposition.

Conclusions:

  • Pediatric nasal spray deposition patterns differ from adults.
  • Anterior deposition may decrease medication effectiveness in children.
  • This can lead to increased drug loss and reduced patient compliance.
Abstract

Keywords:
anterior depositionnasal castnasal spraypediatricsplume angle

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