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Related Experiment Videos

Piroxicam-induced photosensitivity.

A Figueiredo1, C A Ribeiro, S Gonçalo

  • 1Department of Dermatology, University of Coimbra, Portugal.

Contact Dermatitis
|August 1, 1987
PubMed
Summary

Piroxicam therapy can cause photosensitive eruptions, often within 4 days. Experimental studies suggest piroxicam has phototoxic potential, evidenced by increased hemolysis and bacterial growth inhibition upon irradiation.

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Area of Science:

  • Dermatology
  • Photobiology
  • Pharmacology

Background:

  • Photosensitive eruptions are adverse reactions to medications exposed to light.
  • Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) used for pain and inflammation.

Observation:

  • Nine patients developed photosensitive eruptions within 4 days of starting piroxicam.
  • Eruptions required significant medical intervention, including systemic corticosteroids and hospitalization.
  • Clinical and histological studies were inconclusive in classifying the reaction type (photoallergic vs. phototoxic).

Findings:

  • Irradiated piroxicam solutions induced greater hemolysis compared to non-irradiated solutions.
  • Irradiated piroxicam solutions demonstrated enhanced inhibition of Bacillus subtilis growth.

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  • Nuclear magnetic resonance (NMR) spectroscopy showed no spectral changes in piroxicam after irradiation, suggesting a phototoxic mechanism.

    • Implications:

    • The findings provide evidence supporting the phototoxic potential of piroxicam.
    • This highlights the importance of considering piroxicam as a cause of drug-induced photosensitivity.
    • Further research may elucidate the precise mechanisms of piroxicam-induced phototoxicity.