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Prolactin as a candidate sebotrop(h)ic hormone?

Ewan A Langan1,2, Eleanor Hinde2, Ralf Paus2,3

  • 1Department of Dermatology, University of Luebeck, Luebeck, Germany.

Experimental Dermatology
|March 28, 2018
PubMed
Summary
This summary is machine-generated.

The neurohormone prolactin (PRL) influences skin and hair growth. This study suggests PRL may regulate sebaceous glands, offering potential new treatments for skin conditions like acne.

Keywords:
acne vulgarisaginghair follicleprolactinsebaceous gland

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Area of Science:

  • Dermatology
  • Endocrinology
  • Molecular Biology

Background:

  • Prolactin (PRL) is a pleiotropic hormone primarily known for its role in lactation.
  • PRL is expressed in human skin and hair follicles, regulating functions like keratin expression and hair growth.
  • The role of PRL in sebaceous gland (SG) biology is understudied despite clinical observations.

Purpose of the Study:

  • To investigate the potential role of prolactin (PRL) in sebaceous gland (SG) function.
  • To propose PRL as a novel therapeutic target for dermatoses affecting the SG.
  • To identify key research questions and experimental approaches for understanding PRL's impact on SG biology.

Main Methods:

  • Review of existing literature on PRL and cutaneous functions.
  • Analysis of preliminary evidence from human skin organ culture.
  • Discussion of future research directions in PRL and SG biology.

Main Results:

  • Preliminary data suggest PRL influences SG biology.
  • PRL is hypothesized to be a sebotrop(h)ic hormone.
  • Several open questions regarding PRL's role in SG function and pathology were identified.

Conclusions:

  • Prolactin (PRL) may play a significant role in regulating sebaceous gland (SG) function.
  • PRL represents a potential novel therapeutic target for managing acne and other SG-related dermatoses.
  • Further research is needed to elucidate the precise mechanisms and therapeutic applications of PRL in skin health.