IKKs and tumor cell plasticity.

Area of Science:

• Oncology
• Molecular Biology
• Immunology

Background:

• Nuclear factor kappa B (NF-κB) transcription factors are crucial regulators of inflammatory responses, cell survival, proliferation, and cytokine production.
• NF-κB signaling plays a significant role in various stages of cancer development, including initiation, progression, and metastasis.
• Tumor cell plasticity, essential for adaptation and survival in the tumor microenvironment, is influenced by the inflammatory milieu and NF-κB pathways.

Purpose of the Study:

• To review the conventional and non-conventional functions of inhibitor of NF-κB kinases.
• To highlight the role of these kinases in animal models of tumorigenesis.
• To provide insights into NF-κB regulation in the context of cancer.

Main Methods:

• Literature review focusing on recent publications.
• Analysis of studies utilizing animal models of tumorigenesis.
• Examination of the roles of inhibitor of NF-κB kinases in cancer.

Main Results:

• Inhibitor of NF-κB kinases are direct upstream regulators of NF-κB activation.
• These kinases exhibit diverse functions, both conventional and non-conventional, impacting tumor development.
• Evidence from animal models demonstrates their involvement in mediating tumor cell plasticity and survival.

Conclusions:

• Inhibitor of NF-κB kinases are key players in NF-κB-mediated signaling in cancer.
• Understanding their multifaceted roles is critical for developing targeted cancer therapies.
• Further research into these kinases can elucidate mechanisms of tumor adaptation and therapeutic resistance.