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In Vitro Rearing of Solitary Bees: A Tool for Assessing Larval Risk Factors
Published on: July 16, 2018
Amygdala - and serum - neurotrophic factor levels depend on rearing condition in male rats
S Babri1, G Mohaddes2, B Mosaferi3
11Drug Applied Research Center,Tabriz University of Medical Sciences,Tabriz,Iran.
Abstract:
Early life experiences could determine brain and behavioral development. Neurotrophic factors are likely to mediate the effects of the experience on brain structures and function. Brain-derived neurotrophic factor (BDNF) plays a central role in psychiatric disorders. To investigate the effects of early rearing condition on the amygdala - and serum - BDNF levels, we reared male Wistar rats from weaning (postnatal days 21) to adulthood (postnatal days 119) in three different rearing conditions: (1) enriched, (2) standard and (3) isolated. We found that long-term post-weaning environmental enrichment leads to lower amygdala - and serum - BDNF levels as well as lower brain weights. Grouped rearing in standard laboratory cages enhanced body weight. Thus, early rearing condition might play a crucial role in adult healthiness by predetermining individual BDNF profiles.
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