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Progressive outer retinal necrosis after rituximab and cyclophosphamide therapy

Mohit Dogra1, Priya Bajgai1, Ashok Kumar1

  • 1Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Indian Journal of Ophthalmology
|March 28, 2018
PubMed

Insights

Progressive outer retinal necrosis (PORN) occurred in a microscopic polyangitis (MPA) patient on immunosuppressants. Varicella Zoster virus reactivation, potentially due to rituximab, caused necrotizing retinitis.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Rheumatology

Background:

  • Microscopic polyangitis (MPA) is an autoimmune vasculitis often requiring potent immunosuppressive therapy.
  • Immunosuppression, particularly with agents like rituximab and cyclophosphamide, can increase the risk of opportunistic infections.
  • Progressive outer retinal necrosis (PORN) is a severe necrotizing retinitis, typically caused by Varicella Zoster virus (VZV).
Keywords:
Cyclophosphamideprogressive outer retinal necrosisrituximabviral retinitis

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