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COPD 2017: A Year in Review.

Ernesto Crisafulli1, Antoni Torres2

  • 1a Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit , University of Parma , Parma , Italy.

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|March 28, 2018
PubMed
Summary
This summary is machine-generated.

This review summarizes 2017 research on chronic obstructive pulmonary disease (COPD) treatments. It covers tiotropium for mild-moderate COPD, advanced therapies for severe COPD, exacerbation causes, and eosinophil roles in COPD management.

Keywords:
acute exacerbation of COPDchronic obstructive pulmonary diseaseeosinophilsnon-invasive mechanical ventilationpharmacological treatment

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Area of Science:

  • Pulmonology
  • Clinical Medicine
  • Pharmacology

Background:

  • Chronic Obstructive Pulmonary Disease (COPD) presents complex clinical and therapeutic challenges.
  • Recent advancements in 2017 offered new insights into managing COPD patients.
  • Understanding specific treatment strategies and disease triggers is crucial for effective COPD care.

Purpose of the Study:

  • To review original manuscripts from 2017 focusing on clinical and therapeutic aspects of COPD.
  • To synthesize findings on pharmacological and non-pharmacological treatments for mild-moderate and severe COPD.
  • To explore the etiology of COPD exacerbations and the role of eosinophils in disease management.

Main Methods:

  • Systematic review of eight original manuscripts published in 2017 concerning COPD.
  • Categorization of studies into four key topics: tiotropium treatment, severe COPD therapies, exacerbation etiology, and eosinophil-targeted treatments.
  • Analysis of pharmacological (tiotropium, fluticasone furoate/vilanterol/umeclidinium) and non-pharmacological (non-invasive mechanical ventilation) interventions.

Main Results:

  • Tiotropium demonstrated efficacy in mild-moderate COPD patients.
  • Pharmacological (fluticasone furoate/vilanterol/umeclidinium) and non-pharmacological (non-invasive mechanical ventilation) approaches showed promise for severe COPD.
  • Seasonal airway pathogens were identified as significant contributors to acute exacerbations.
  • Eosinophil involvement, particularly with monoclonal antibodies like mepolizumab targeting interleukin-5, was highlighted.

Conclusions:

  • The reviewed studies provide valuable updates on COPD management strategies.
  • Tailored pharmacological and non-pharmacological treatments are essential for different COPD severities.
  • Further research into exacerbation triggers and immunomodulatory therapies like mepolizumab is warranted for improved COPD outcomes.