Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sleepwalking and Sleep Talking01:17

Sleepwalking and Sleep Talking

1.0K
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
1.0K
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

5.8K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.8K
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

273
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
273
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

213
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
213
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

226
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
226
Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

925
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
925

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cohesin collisions maintain ordered nucleosome architecture at boundaries and promoters.

bioRxiv : the preprint server for biology·2026
Same author

A tunable Cas12a platform for single-cell perturbation screening and CRISPRi.

Nature communications·2026
Same author

Motif grammar and transcriptional programs decouple CTCF binding from nucleosome phasing to control cell-type-specific chromatin insulation.

Cell reports·2026
Same author

Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination.

bioRxiv : the preprint server for biology·2026
Same author

A Targetable Developmental Program Coregulates Angiogenesis and Immune Evasion in Melanoma.

Cancer discovery·2026
Same author

Phasing single-molecule nano-NOMe-seq reveals chromatin state heterogeneity in the context of transcription and long-range interactions.

bioRxiv : the preprint server for biology·2025
Same journal

HOTAIR at the metabolic crossroads: lncRNA control of carbohydrate and lipid metabolism.

Epigenomics·2026
Same journal

Long-term molecular embedding of early life adversity: leukocyte DNA methylation and gene expression associations from childhood to young adulthood.

Epigenomics·2026
Same journal

Overview of transcriptomics and epigenomics approaches in the diagnosis, prognosis, and therapeutics of primary brain cancers.

Epigenomics·2026
Same journal

Ultra-sensitive urine DNA methylation test enables early and accurate detection of bladder cancer.

Epigenomics·2026
Same journal

Promoter methylation-associated brain-enriched long noncoding RNAs in glioblastoma: a multi-cohort public epigenomic re-analysis.

Epigenomics·2026
Same journal

Clinical diagnostic utility of <i>MGMT</i> promoter methylation.

Epigenomics·2026
See all related articles

Related Experiment Video

Updated: Feb 12, 2026

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
10:46

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines

Published on: June 2, 2018

9.8K

Enhancer talk.

Valentina Snetkova1,2, Jane A Skok1

  • 1Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB 599, New York, NY 10016, USA.

Epigenomics
|March 28, 2018
PubMed
Summary
This summary is machine-generated.

Enhancers, DNA segments regulating gene activity, can be distant and clustered. This study explores how chromatin conformation influences enhancer function and discusses methods for identifying these crucial regulatory elements.

Keywords:
3D conformationCTCFLCRsTADschromatin contactscohesinenhancersstretch enhancerssuper enhancers

More Related Videos

Studying Cavitation Enhanced Therapy
07:36

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

5.9K
Mosaic Zebrafish Transgenesis for Evaluating Enhancer Sequences
07:23

Mosaic Zebrafish Transgenesis for Evaluating Enhancer Sequences

Published on: July 16, 2010

14.4K

Related Experiment Videos

Last Updated: Feb 12, 2026

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
10:46

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines

Published on: June 2, 2018

9.8K
Studying Cavitation Enhanced Therapy
07:36

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

5.9K
Mosaic Zebrafish Transgenesis for Evaluating Enhancer Sequences
07:23

Mosaic Zebrafish Transgenesis for Evaluating Enhancer Sequences

Published on: July 16, 2010

14.4K

Area of Science:

  • Genetics
  • Molecular Biology
  • Epigenetics

Background:

  • Enhancers are DNA segments (100-1000 bp) that regulate gene activity spatially and temporally.
  • These distal regulatory elements can be located far from their target genes, making identification challenging.
  • Enhancers often form clusters to control a single gene's expression, but individual contributions are poorly understood.

Purpose of the Study:

  • To investigate the role of chromatin conformation in promoting and constraining enhancer activity.
  • To explore the dynamics of enhancer clusters and the contribution of individual elements to gene regulation.
  • To evaluate the reliability of various methods used for enhancer identification.

Main Methods:

  • Analysis of chromatin conformation dynamics.
  • Investigating enhancer-gene interactions within clusters.
  • Comparative assessment of enhancer identification techniques.

Main Results:

  • Chromatin conformation plays a dual role in regulating enhancer activity.
  • Understanding enhancer clusters requires dissecting individual element contributions.
  • Methodological reliability for enhancer identification varies.

Conclusions:

  • Chromatin conformation is a key factor in enhancer function and regulation.
  • Further research is needed to elucidate the precise roles of individual enhancers within clusters.
  • Reliable identification methods are crucial for advancing our understanding of gene regulation.