Immunologic investigation of recurrent pregnancy loss and consequences of immunization with husbands' leukocytes

A significant association was found between absence of cytotoxicity to husbands' lymphocytes and of MLC suppression, both of which were absent more commonly in primary than secondary abortion. Following immunization with husbands' leukocytes, systemic side effects were common and cytotoxicity became positive in all but two of eight women tested, both of whom also failed to develop MLC suppression.