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Related Experiment Videos

Cutaneous reactions to nifedipine.

J Alcalay1, M David, M Sandbank

  • 1Department of Dermatology, Beilinson Medical Center, Petah Tiqva Sackler School of Medicine, Tel Aviv University, Israel.

Dermatologica
|January 1, 1987
PubMed
Summary

Nifedipine, a calcium-channel blocker, rarely causes skin reactions. This study reports the first documented case of a fixed drug eruption linked to nifedipine use.

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Area of Science:

  • Pharmacology
  • Dermatology
  • Clinical Medicine

Background:

  • Nifedipine is a widely prescribed calcium-channel blocker for angina and hypertension.
  • Cutaneous adverse drug reactions to nifedipine are exceptionally rare in clinical practice.

Observation:

  • A literature review identified only three previously reported cutaneous eruptions associated with nifedipine: vasculitis, leg edema, and erythromelalgia.
  • This paper details a novel case of a patient experiencing a fixed drug eruption.

Findings:

  • The study presents the first documented instance of a fixed drug eruption specifically attributed to nifedipine.
  • This finding expands the known spectrum of nifedipine-induced dermatological side effects.

Implications:

  • Clinicians should consider fixed drug eruption in the differential diagnosis of cutaneous reactions to nifedipine.
  • This case highlights the importance of pharmacovigilance for even rare adverse events associated with commonly used medications.

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