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Related Experiment Videos

[Contact allergy to bufexamac].

P J Frosch1, C Raulin

  • 1Universitäts-Hautklinik Heidelberg.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|June 1, 1987
PubMed
Summary
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Contact allergy to bufexamac, a topical anti-inflammatory, can occur, even with short-term use. This rare allergy is a potential cause of sensitization in patients with chronic eczema.

Area of Science:

  • Dermatology
  • Allergology
  • Pharmacovigilance

Context:

  • Contact allergy to bufexamac has been observed in clinical practice.
  • Patients often present with chronic eczema or stasis dermatitis.
  • The condition can manifest even after brief exposure to the topical agent.

Purpose:

  • To report cases of contact allergy to bufexamac.
  • To describe the clinical presentation and patient demographics.
  • To assess the significance of bufexamac as a contact allergen.

Summary:

  • Thirteen cases of bufexamac contact allergy were identified since 1976.
  • The majority of affected patients were women with chronic eczema or stasis dermatitis.
  • Allergic contact dermatitis was the consistent clinical picture, with some cases showing generalized reactions and co-existing sensitizations, including to benzyl alcohol preservative.

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Impact:

  • Highlights bufexamac as a potential contact allergen.
  • Emphasizes the importance of considering bufexamac allergy in refractory eczema cases.
  • Suggests vigilance for sensitization, even with short-term bufexamac application.