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Assembling the Puzzle of Apixaban Solid Forms.

Rafael Barbas1, Cristina Puigjaner1, Rafel Prohens1

  • 1Unitat de Polimorfisme i Calorimetria, Centres Científics i Tecnològics , Universitat de Barcelona , Baldiri Reixac 10 , 08028 Barcelona , Spain.

Molecular Pharmaceutics
|March 28, 2018
PubMed
Summary
This summary is machine-generated.

This study clarifies the solid forms of Apixaban (APX), an anticoagulant, resolving literature confusion. A comprehensive screen and comparison provide a reliable overview of APX solid forms.

Keywords:
patentspharmaceutical drugspolymorphismpowder X-ray diffraction

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Area of Science:

  • Pharmaceutical Sciences
  • Solid-State Chemistry

Background:

  • The scientific and patent literature contains confusion regarding the solid forms of Apixaban (APX).
  • Unclear nomenclature and incomplete characterization data obscure the solid forms landscape.
  • This ambiguity leads to conflicting reports and patent claims for the same Apixaban forms.

Purpose of the Study:

  • To conduct an in-depth analysis of Apixaban solid forms.
  • To resolve the confusion in existing scientific and patent literature.
  • To establish a reliable understanding of the Apixaban solid forms landscape.

Main Methods:

  • A comprehensive screening for Apixaban solid forms was performed.
  • Literature data on Apixaban solid forms was carefully compared.
  • Characterization data was critically evaluated for clarity and completeness.

Main Results:

  • Identified and characterized various solid forms of Apixaban.
  • Resolved discrepancies in nomenclature and data reporting in the literature.
  • Established a clear and reliable picture of the Apixaban solid forms landscape.

Conclusions:

  • The study provides a definitive overview of Apixaban solid forms.
  • Clarified nomenclature and characterization data enhance understanding.
  • This work aids researchers and patent holders in navigating Apixaban's solid-state properties.