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Molecular Characterization and Mortality From Breast Cancer in Men.

Suleiman Alfred Massarweh¹, George W Sledge¹, Dave P Miller¹

¹Suleiman Alfred Massarweh and George W. Sledge, Stanford University School of Medicine and Stanford Cancer Institute, Stanford; Dave P. Miller, Debbie McCullough, and Steven Shak, Genomic Health, Redwood City, CA; and Valentina I. Petkov, National Cancer Institute, Bethesda, MD.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology

|March 28, 2018

Summary

This study found distinct biological features in male breast cancer, with higher recurrence scores (RS) and lower survival rates compared to women. The 21-gene Breast Recurrence Score (RS) is a valuable prognostic tool for both genders.

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Area of Science:

Oncology
Genomics
Endocrinology

Background:

Limited data exist on male breast cancer molecular biology, treatment, and outcomes.
Understanding of male breast cancer is often extrapolated from female breast cancer data.

Purpose of the Study:

To investigate the molecular biology, treatment, and outcomes of male breast cancer.
To compare clinical characteristics, gene expression, and prognostic value of the 21-gene Breast Recurrence Score (RS) between men and women with hormone receptor-positive breast cancer.

Main Methods:

Analysis of clinical characteristics and gene expression in 3,806 men and 571,115 women with hormone receptor-positive breast cancer.
Correlation of 21-gene Breast Recurrence Score (RS) distribution with 5-year breast cancer-specific survival (BCSS) and overall survival using SEER data.

Main Results:

Men were older than women, with a higher frequency of high (RS ≥ 31) and very low (RS < 11) recurrence scores.
Mean gene expression was higher in men for estrogen receptor (ER), proliferation, and invasion groups.
Five-year BCSS and overall survival were lower in men than in women, with RS ≥ 31 associated with poorer outcomes in men.

Conclusions:

Male breast cancer exhibits distinct biological features compared to female breast cancer.
The 21-gene Breast Recurrence Score (RS) demonstrates prognostic value in both men and women.
Further research is needed to understand the unique aspects of male breast cancer biology and optimize treatment strategies.