Quality before Quantity: Inspecting CFTR
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Updated: Feb 12, 2026

Fast Inspection of Quality of Indigo Naturalis by Multiple Light Scattering
Published on: August 18, 2023
1The Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Jackson 1402, 55 Fruit Street, Boston, MA 02114, USA; Massachusetts General Hospital for Children, Pediatric Pulmonary Medicine, Boston, MA, USA.
Abstract:
CFTR biosynthesis is highly dynamic. In this issue of Developmental Cell, Okiyoneda et al. (2018) show that RFFL serves as a CFTR conformation scrutinizer at the plasma membrane. It recognizes misfolded CFTR proteins and marks them for degradation. This quality control mechanism may be explored to benefit cystic fibrosis patients.
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