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A Prospective Trial of Nebulized Amikacin in the Treatment of Bronchiectasis Exacerbation

Yirepanjaing Ailiyaer1, Xiuxiu Wang1, Yan Zhang1

  • 1Department of Respiratory Medicine, Qilu Hospital of Shandong University, Jinan, China.

Respiration; International Review of Thoracic Diseases
|March 28, 2018
PubMed
Abstract

Insights

Nebulized amikacin effectively eradicates Pseudomonas aeruginosa in bronchiectasis patients. This safe treatment significantly improves sputum bacterial clearance during exacerbations.

Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Pseudomonas aeruginosa is a common pathogen in bronchiectasis (BE).
  • The efficacy and safety of nebulized amikacin for BE exacerbations remain unclear.

Purpose of the Study:

  • To evaluate the efficiency and safety of 2-week nebulized amikacin treatment for BE patients with P. aeruginosa infection during exacerbations.

Main Methods:

  • 143 BE patients with P. aeruginosa exacerbations were randomized.
  • Intervention group received nebulized amikacin plus intravenous antibiotics.
  • Control group received standard intravenous antibiotics alone.

Main Results:

  • Bacterial eradication rate was significantly higher in the amikacin group (51.4%) versus control (23.2%).
  • No significant difference in drug resistance between groups.
  • Adverse effects led to 3 dropouts; no renal injury observed.

Conclusions:

  • Nebulized amikacin is a safe and effective treatment for P. aeruginosa exacerbations in BE patients.
  • Nebulized amikacin significantly enhances sputum bacterial eradication.
Keywords:
Bacteria eradication rateBronchiectasisNebulized amikacin treatmentPseudomonas aeruginosa

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