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Updated: Feb 12, 2026
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Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
Published on: September 20, 2011
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Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin
Anita Umerska1, Caroline Gaucher2, Felipe Oyarzun-Ampuero3
1Université de Lorraine, CITHEFOR, F-54000 Nancy, France. anita.umerska@univ-lorraine.fr.
Antioxidants (Basel, Switzerland)
|March 29, 2018
Summary
Curcumin
Area of Science:
- Pharmaceutical Technology
- Nanotechnology
- Drug Delivery
Background:
- Curcumin exhibits potent biological and antioxidant properties but faces limitations in medical use due to poor water solubility and low oral bioavailability.
- Polymeric nanoparticles (NPs) offer a potential strategy to enhance curcumin's oral delivery and overcome its bioavailability challenges.
Purpose of the Study:
- To develop and evaluate polymeric nanoparticles for oral curcumin delivery.
- To assess nanoparticle characteristics, solid-state storage stability, in vitro release, and cytocompatibility.
Main Methods:
- Curcumin was encapsulated into Eudragit® RLPO (ERL), poly(lactic-co-glycolic acid) (PLGA), and polycaprolactone (PCL) nanoparticles.
- Particle size, zeta potential, morphology, encapsulation efficiency, redispersibility after freeze-drying, in vitro dissolution, and intestinal cell cytocompatibility were evaluated.
Main Results:
- Eudragit® RLPO (ERL) nanoparticles demonstrated smaller particle sizes and superior redispersibility after freeze-drying compared to PLGA and PCL nanoparticles.
- While ERL NPs had lower encapsulation efficiency, they exhibited rapid curcumin release (91% in 1 hour).
- All tested curcumin-loaded nanoparticles were compatible with intestinal cells.
Conclusions:
- Eudragit® RLPO (ERL) nanoparticles show significant promise as effective vehicles for enhancing the oral bioavailability of curcumin.
- The developed nanoparticle formulations are suitable for oral administration and demonstrate good cytocompatibility.
Keywords:
EudragitPCLPLGAcurcumincytocompatibilityintestinal cellsnanoparticlessingle emulsion-solvent evaporation methodMore Related Videos
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