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Updated: Feb 12, 2026

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Published on: November 4, 2012
In Vivo Bioluminescence Imaging of Cobalt Accumulation in a Mouse Model
Bowen Ke1, Lin Ma2, Ting Kang1
1Department of Anaesthesiology & Critical Care Medicine , Translational Neuroscience Center, West China Brain Research Center, West China Hospital, Sichuan University , Chengdu , Sichuan 610041 , China.
Abstract:
As a trace element nutrient, cobalt is critical for both prokaryotes and eukaryotes. In the current study, a turn-on Cobalt Bioluminescent Probe 1 (CBP-1) for the detection of cobalt has been successfully developed based on oxidative C-O bond cleavage. This probe exhibited high selectivity and sensitivity toward cobalt over other analytes. By using CBP-1, the successful in vivo imaging of cobalt accumulation was carried out in a mouse model. Such an ability to determine cobalt in living animals provides a powerful technology for studying the system distribution, toxic potency, and biological effect of Co2+.
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