Related Experiment Video

Updated: Feb 12, 2026

Orthotopic Aortic Transplantation: A Rat Model to Study the Development of Chronic Vasculopathy
08:32

Orthotopic Aortic Transplantation: A Rat Model to Study the Development of Chronic Vasculopathy

Published on: December 4, 2010

12.7K

Orthotopic heart transplantation in children

Nagarajan Muthialu1

  • 1Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Sick Children, London, UK.

Asian Cardiovascular & Thoracic Annals
|March 29, 2018
PubMed

Insights

Pediatric heart transplantation, while complex, offers good survival rates for children with heart conditions. Advances in care and donor availability are improving outcomes, with devices bridging patients to transplant.

Area of Science:

  • Pediatric Cardiac Surgery
  • Cardiology
  • Transplantation Medicine

Background:

  • Pediatric heart transplantation is a complex procedure, increasingly offered to infants with congenital heart disease due to improved intensive care.
  • Primary cardiomyopathies are the leading indication for pediatric heart transplants.
  • Historically, heart transplantation was reserved for older children, but this is changing.

Purpose of the Study:

  • To review the current status of pediatric heart transplantation.
  • To discuss advancements in intensive care, diagnostics, and management impacting infant heart transplantation.
  • To highlight challenges and successes in pediatric cardiothoracic transplantation.

Main Methods:

  • Review of current literature and clinical practices in pediatric heart transplantation.
  • Discussion of organ acceptance criteria and surgical techniques.
  • Analysis of outcomes and donor availability trends.

Main Results:

  • Outcomes in cardiothoracic transplantation have significantly improved.
  • Increased public awareness and donation after cardiac death have boosted donor availability, particularly for lungs.
  • Mechanical circulatory support devices are effectively bridging pediatric patients to transplantation.

Conclusions:

  • Pediatric heart transplantation demonstrates a reasonably good survival rate across various recipient conditions.
  • Despite ongoing donor shortages, advancements have improved the overall outlook for pediatric heart recipients.
  • Technical aspects of simple and complex pediatric heart transplantation are crucial for successful outcomes.

Keywords:
Blood group incompatibilityCardiomyopathiesChildHeart defectsHeart transplantationHeart-assist devicescongenital

More Related Videos

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation09:12

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation

Published on: April 27, 2019

10.1K
Orthotopic Hind Limb Transplantation in the Mouse07:15

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

12.4K

Related Concept Videos

Anatomy of the Heart01:27

Anatomy of the Heart

The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
120.6K
Anatomy of the Heart01:20

Anatomy of the Heart

The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
3.3K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
324
Overview of the Heart01:07

Overview of the Heart

The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
14.2K
Conduction System of the Heart01:19

Conduction System of the Heart

Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
13.6K
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.1K