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Predictive role of endothelin in left ventricular remodeling of chronic kidney disease
1a Department of Nephrology , Shandong University Qilu Hospital , Jinan , P. R. China.
Insights
Serum endothelin-1 (ET-1) levels predict cardiac complications in chronic kidney disease (CKD) patients. Elevated ET-1 correlates with heart structure changes, aiding in early detection of cardiovascular issues in CKD.
Area of Science:
- Nephrology
- Cardiology
- Biomarkers
Background:
- Chronic kidney disease (CKD) is associated with elevated endothelin-1 (ET-1) levels.
- Cardiac ultrasonography often reveals structural changes in CKD patients.
- The role of serum ET-1 in predicting cardiac complications in CKD requires further investigation.
Purpose of the Study:
- To investigate the predictive role of serum ET-1 in cardiac complications among CKD patients.
- To determine the correlation between serum ET-1 levels and cardiac structural changes in CKD.
Main Methods:
- Serum ET-1 levels were quantified using enzyme-linked immunosorbent assay (ELISA).
- Cardiac ultrasonography was performed to assess heart structure.
- Key echocardiographic parameters including left ventricular mass index, interventricular septum thickness, and left ventricular end diastolic diameter were measured.
Main Results:
- Serum ET-1 levels showed a significant correlation with left ventricular mass index (p < .001).
- Serum ET-1 levels were significantly correlated with interventricular septum thickness (p < .001).
- A significant correlation was observed between serum ET-1 levels and left ventricular end diastolic diameter (p < .001) in non-dialysis CKD patients.
Conclusions:
- Serum ET-1 levels are closely associated with cardiac complications in CKD.
- Serum ET-1 serves as a valuable predictive marker for cardiac complications in CKD patients.
Background:
In chronic kidney disease (CKD), endothelin-1 (ET-1) always increases and there are changes in cardiac ultrasonography. In the present study, we aimed at investigating the role of serum ET-1 in predicting cardiac complications in patients with CKD.
Methods:
The level of serum ET-1 was measured by enzyme-linked immunosorbent assay (ELISA) and cardiac ultrasonography was performed in enrolled patients. Indexes of heart failure, such as left ventricular mass index, interventricular septum thickness and left ventricular end diastolic diameter, were measured in patients with CKD.
Results:
In the present study, we found that the level of serum ET-1 was significantly correlated with left ventricular mass index, interventricular septum thickness and left ventricular end diastolic diameter (p < .001) in non-dialysis patients with CKD.
Conclusions:
The results of the present study indicated that the level of serum ET-1 is closely related to the cardiac complications of CKD and is a useful predictor of cardiac complication.
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