Xenon Anesthesia and CT: Noninvasive Measures of Brain Anesthetic Concentration
Andrew McKinstry-Wu1, Charles W Carspecken1, Alex Proekt1
1University of Pennsylvania, Philadelphia, PA, United States.
Abstract:
The existence of a barrier between anesthetic behavioral state transitions has been observed across phyla, but demonstrating that such a barrier exists and is not a pharmacokinetic artifact has not yet been possible in humans. Such an investigation requires temporally precise information regarding the brain concentration of anesthetic in order to demonstrate the specific pharmacokinetic-pharmacodynamic mismatch that is hysteresis. We propose a method to noninvasively determine brain tissue anesthetic concentration using computerized tomography and the radiopaque gaseous anesthetic xenon. Such a technique can be used to investigate pharmacokinetic-pharmacodynamic mismatches in humans.
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