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Exploiting interfacial phenomena in organic bioelectronics: Conformable devices for bidirectional communication with
Michele Di Lauro1, Simone Benaglia1, Marcello Berto1
1Dipartimento di Scienze della Vita, Università di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Colloids and Surfaces. B, Biointerfaces
|March 29, 2018
Summary
Researchers developed a new organic bioelectronic device using poly(3,4-ethylenedioxythiophene):polystyrene sulfonate) (PEDOT:PSS) electrodes. This device enables bidirectional communication with the brain, showing promise for neurodegenerative disease treatments.
Area of Science:
- Bioelectronic Engineering
- Neuroscience
- Materials Science
Background:
- Brain implants require advanced electronic interfaces for effective communication.
- Current devices face limitations in biocompatibility and signal transduction efficiency.
- Organic bioelectronics offer a promising avenue for next-generation neural interfaces.
Purpose of the Study:
- To present and validate a novel fully organic bioelectronic device.
- To demonstrate its capability as an electronic transducer and current stimulator for brain implants.
- To explore its potential for bidirectional communication with biological systems.
Main Methods:
- Fabrication of polymeric electrodes using poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) on thin foils.
- Development of a high surface-to-volume ratio architecture.
- Assessment of transduction of ultra-low local-field potentials and delivery of voltage pulse-trains.
Main Results:
- The device demonstrated high sensitivity to interfacial ionic transport phenomena.
- Successful transduction of ultra-low local-field potentials was achieved.
- Effective delivery of voltage pulse-trains, similar to deep-brain stimulation, was validated.
Conclusions:
- The novel organic bioelectronic device serves as a viable electronic transducer and current stimulator.
- The prototyping technique allows for controlled dimensionality for various applications.
- This technology paves the way for new theranostic strategies for Parkinson's Disease and other CNS disorders.
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