Related Experiment Video For Adenoma
Updated: Feb 12, 2026
Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
Published on: February 10, 2023
Number of advanced adenomas on index colonoscopy: Important risk factor for metachronous advanced colorectal
Soo-Kyung Park1, Hyo-Joon Yang1, Yoon Suk Jung1
1Division of Gastroenterology, Department of Internal Medicine and Gastrointestinal Cancer Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Background/Aims:
Although the patients with multiple advanced adenomas (AA) in index colonoscopy may have an increased risk for subsequent advanced colorectal neoplasia (CRN), the current guidelines do not consider this factor. We aimed to compare the risk of metachronous advanced CRN according to the number of AAs.
Methods:
A total of 2250 patients with ≥1 adenoma at index colonoscopy were included. The patients were divided according to the number of AAs (1, 2 and ≥3 AAs). The relative and 3-year absolute risk of metachronous advanced CRN was compared between the AA groups.
Results:
The relative risk of metachronous advanced CRN was higher in the patients with ≥3 AAs than in the patients with one AA (16.7% vs. 6.8%, p = 0.004). The 3-year absolute risk of metachronous advanced CRN was higher in the patients with ≥3 AAs than in the patients with 1-2 AA (19.4% vs. 6.9%, p = 0.04). Having ≥3 AAs (odds ratio, 5.42; 95% confidence interval 1.75-16.83) was a significant risk factor for developing advanced CRN.
Conclusions:
The risk of metachronous advanced CRN in the patients with ≥3 AAs was higher than that in the patients with one or two AAs. More intensive surveillances might be needed for these patient groups.
Related Concept Videos
02:22Overview of Advanced Functional Groups
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
00:56Extraction: Advanced Methods
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:08Sample Preparation for Analysis: Advanced Techniques
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
01:24Drug Toxicity: Risk factors
01:30Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques