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Updated: Feb 12, 2026

An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
Utility of multimodality cardiac imaging in disorders of the pericardium
Bo Xu1,2,3, Serge C Harb1,2,3, Allan L Klein1,2,3
1Xu B, Section of Cardiovascular Imaging, Center for the Diagnosis and Treatment of Pericardial Diseases, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
Insights
Advances in cardiovascular imaging, especially cardiac magnetic resonance (CMR), are improving the diagnosis and treatment of pericarditis and other pericardial diseases. This review highlights imaging modalities for better patient care.
Area of Science:
- Cardiology
- Medical Imaging
- Pathophysiology
Background:
- Pericardial diseases historically lacked research and advanced diagnostics.
- Limited evidence-based treatments hindered management.
- Recent interest driven by imaging and understanding inflammation.
Purpose of the Study:
- Review the role of multimodality cardiovascular imaging in pericardial conditions.
- Focus on echocardiography, MDCT, and CMR.
- Highlight strengths and limitations of each modality.
Main Methods:
- Review of current literature on pericardial disease imaging.
- Analysis of echocardiography, multidetector cardiac computed tomography (MDCT), and cardiac magnetic resonance (CMR).
- Comparative assessment of imaging modalities' utility.
Main Results:
- Cardiac magnetic resonance (CMR) shows promise in guiding treatment for pericardial syndromes.
- Understanding inflammation's role in pericarditis aids in identifying treatment targets.
- Multimodality imaging offers a comprehensive approach to diagnosis.
Conclusions:
- Multimodality imaging, particularly CMR, is revolutionizing pericardial disease diagnosis.
- Advances in understanding pericarditis pathophysiology open avenues for targeted therapies.
- This review provides practical insights for clinicians managing pericardial conditions.
Abstract:
Disorders of the pericardium represent a diverse range of conditions that traditionally may not have received the same level of attention by cardiologists and physicians, owing partly to a lack of research into advanced diagnostic modalities, and limited, evidence-based treatment options. In recent years, there has been a timely resurgence of interest in pericardial diseases, in particular pericarditis. This is attributable to advances in multi-modality cardiovascular imaging, in particular cardiac magnetic resonance (CMR), which may help guide treatment decisions for patients with pericardial syndromes. Additionally, increased research and understanding of the pathophysiological basis of pericarditis have shed light on the role of inflammation in pericarditis. This knowledge may help identify potential specific treatment targets. This article aims to provide a practical review of the role of multimodality cardiovascular imaging (echocardiography, multidetector cardiac computed tomography (MDCT), CMR) in pericardial conditions, focusing on the strengths and potential limitations of each imaging modality.
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