Related Experiment Video

Updated: Feb 12, 2026

Transurethral Induction of Mouse Urinary Tract Infection
09:24

Transurethral Induction of Mouse Urinary Tract Infection

Published on: August 5, 2010

37.4K

Risks of irritable bowel syndrome in children with infantile urinary tract infection: a 13-year nationwide cohort

Teck-King Tan1, Miguel Saps2, Cheng-Li Lin3,4

  • 1Department of Pediatrics, Children's Hospital, China Medical University Hospital, Taichung, Taiwan.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|March 29, 2018
PubMed

Insights

Infant urinary tract infections (UTI) increase the risk of developing childhood irritable bowel syndrome (IBS). This risk is higher with recurrent UTIs or when accompanied by vesicoureteral reflux (VUR).

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Urology

Background:

  • Early life events significantly influence the development of irritable bowel syndrome (IBS).
  • Cross-organ sensitization between the bladder and colon is a suspected mechanism.
  • The association between infant urinary tract infection (UTI) and childhood IBS is not well-established.

Purpose of the Study:

  • To investigate whether infant urinary tract infection (UTI) is a risk factor for developing childhood irritable bowel syndrome (IBS).
  • To quantify the risk of childhood IBS in infants with a history of UTI.

Main Methods:

  • Retrospective cohort study involving 31,788 infants with UTI and 127,152 matched controls without UTI.
  • Data collected between 2000 and 2011, with follow-up until the end of 2012.
  • Incidence density and hazard ratios (HRs) for IBS were calculated and compared between cohorts.

Main Results:

  • The incidence density of IBS was 1.52-fold higher in the UTI cohort compared to the non-UTI cohort.
  • Higher risks of IBS were observed in children with more frequent UTI-related medical visits, longer hospitalizations, and concurrent vesicoureteral reflux (VUR).
  • The hazard ratio for IBS was slightly higher in boys than in girls.

Conclusions:

  • Infants with a history of UTI exhibit a significantly higher risk of developing childhood IBS.
  • The risk of childhood IBS increases with the severity and recurrence of UTI, particularly when VUR is present.
  • Findings highlight the importance of considering early-life UTIs in the context of pediatric functional gastrointestinal disorders.

Keywords:
infantirritable bowel syndromeurinary tract infection

More Related Videos

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection07:57

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection

Published on: June 24, 2025

1.2K
Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging07:39

Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging

Published on: June 14, 2021

3.5K

Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.1K
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
889
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
850
Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
740
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
799
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
330