Related Experiment Video

Updated: Feb 12, 2026

Intracranial Implantation with Subsequent 3D In Vivo Bioluminescent Imaging of Murine Gliomas
09:46

Intracranial Implantation with Subsequent 3D In Vivo Bioluminescent Imaging of Murine Gliomas

Published on: November 6, 2011

21.3K

Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes

Ming Zhao1, Mengnan Zhao1, Chen Fu1

  • 1School of Pharmaceutical Sciences, Southwest University, Chongqing, People's Republic of China.

International Journal of Nanomedicine
|March 29, 2018
PubMed
Abstract

Insights

Novel brain-targeting nanoliposomes loaded with curcumin effectively treated glioma in mice. These RDP-modified liposomes (RCL) improved survival by targeting brain tumors and inducing cell death.

Area of Science:

  • Nanomedicine
  • Biotechnology
  • Oncology

Background:

  • Glioma is a highly aggressive and lethal brain tumor, accounting for 30% of all brain and central nervous system tumors.
  • Effective therapeutic strategies for glioma remain a significant challenge in neuro-oncology.

Purpose of the Study:

  • To develop novel brain-targeting nanoliposomes for encapsulating curcumin, a potential glioma therapeutic agent.
  • To enhance curcumin delivery to brain tumors using targeted nanoliposomes.

Main Methods:

  • Human glioma cells (U251MG) were used to assess the cellular uptake and internalization mechanisms of curcumin-loaded nanoliposomes modified with the RDP brain-targeting peptide.
  • An intracranial glioma mouse model was established, and RDP-modified liposomes (RCL) were administered intravenously to evaluate anti-glioma activity.

Main Results:

  • RDP-modified liposomes (RCL) demonstrated brain penetration and accumulation in the glioma region.
  • Glioma cells internalized RCL, potentially via acetylcholine receptor-mediated endocytosis.
  • RCL treatment significantly prolonged survival in glioma-bearing mice (from 23 to 33 days).
  • RCL inhibited glioma cell growth through cell cycle arrest at the S phase and induced apoptosis.

Conclusions:

  • This study presents a promising strategy for targeted delivery of liposomal drugs for enhanced glioma treatment.
  • RDP-modified nanoliposomes offer a potential platform for improving the efficacy of curcumin-based glioma therapies.
Keywords:
cell apoptosiscell cyclegliomasurvival timetargeted delivery

More Related Videos

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation14:10

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

16.5K
A Simple Guide Screw Method for Intracranial Xenograft Studies in Mice08:11

A Simple Guide Screw Method for Intracranial Xenograft Studies in Mice

Published on: September 26, 2011

23.7K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Modeling in Therapy01:26

Modeling in Therapy

Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
509
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Group Therapy01:26

Group Therapy

Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
460
Behavior Therapy01:22

Behavior Therapy

Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
735
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
304