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STAT3, stem cells, cancer stem cells and p63
Michaela Galoczova1, Philip Coates1, Borivoj Vojtesek1
1Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic.
Cellular & Molecular Biology Letters
|March 29, 2018
Summary
Signal Transducer and Activator of Transcription 3 (STAT3) regulates stem cells and cancer stem cells. This review explores STAT3
Area of Science:
- Molecular Biology
- Cell Biology
- Cancer Research
Background:
- Signal Transducer and Activator of Transcription 3 (STAT3) is a crucial transcription factor.
- STAT3 plays diverse roles in normal and cancerous cells, including stem cell regulation.
- The p63 protein, part of the p53 family, interacts with STAT3.
Purpose of the Study:
- To review the complex regulation and functions of STAT3.
- To elucidate STAT3's role in normal and cancer stem cells.
- To highlight the relationship between STAT3 and p63.
Main Methods:
- Literature review of STAT3 and p63.
- Analysis of signaling pathways involving STAT3.
- Examination of STAT3's role in stem cell biology.
Main Results:
- STAT3 is a key regulator of both normal and cancer stem cells.
- STAT3 and p63 are physically and functionally interconnected.
- STAT3's complex regulation impacts various cellular processes.
Conclusions:
- STAT3 is central to stem cell properties and cancer stem cell maintenance.
- The interplay between STAT3 and p63 is significant for cellular functions.
- Understanding STAT3 and p63 interactions offers therapeutic insights.
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