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Related Experiment Video

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Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
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Fractional Flow Reserve: Does a Cut-off Value add Value?

Shah R Mohdnazri1,2, Thomas R Keeble1,2, Andrew Sp Sharp3,4

  • 1The Essex Cardiothoracic Centre, Basildon, UK.

Interventional Cardiology (London, England)
|March 29, 2018
PubMed
Summary
This summary is machine-generated.

Fractional flow reserve (FFR) guidance for percutaneous coronary intervention (PCI) has evolved. The FFR cut-off value of ≤0.80 is now standard in clinical practice, replacing the older ≤0.75 threshold.

Keywords:
Coronary physiologyfractional flow reservepressure wire

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Area of Science:

  • Cardiology
  • Interventional Cardiology

Background:

  • Fractional flow reserve (FFR) is crucial for guiding percutaneous coronary intervention (PCI).
  • Historically, FFR cut-off values of ≤0.75 and ≥0.75 were used, with a 'grey zone' between 0.76-0.80.
  • Clinical judgement was advised for FFR values within the grey zone due to suboptimal test performance.

Purpose of the Study:

  • To review the data supporting FFR cut-off values for PCI guidance.
  • To discuss the practical implications of current FFR cut-off values in clinical practice.

Main Methods:

  • Analysis of data from landmark studies (DEFER, FAME).
  • Review of clinical practice guidelines regarding FFR use.

Main Results:

  • The FFR cut-off point of ≤0.80, established by the FAME studies, is now widely adopted in clinical guidelines.
  • The older FFR cut-off of ≤0.75 is no longer the primary standard for guiding PCI.
  • The FAME studies demonstrated the utility of ≤0.80 for predicting outcomes.

Conclusions:

  • The current standard for FFR guidance in PCI is a cut-off value of ≤0.80.
  • Understanding the evolution of FFR cut-offs is essential for optimal patient management.