Related Experiment Video
Updated: Feb 12, 2026
08:42
Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
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Challenging current views on bile acid diarrhoea and malabsorption
Matthew Kurien1, Elizabeth Thurgar2, Ashley Davies2
1Academic Unit of Gastroenterology, Department of Infection, Immunity and Cardiovascular Sciences, University of Sheffield, Sheffield, UK.
Frontline Gastroenterology
|March 29, 2018
Summary
Bile acid malabsorption (BAM), or bile acid diarrhoea (BAD), is more common than previously thought. New evidence supports tauroselcholic (75selenium) acid scanning as a key diagnostic tool for BAM.
Area of Science:
- Gastroenterology
- Diagnostic Imaging
- Clinical Medicine
Background:
- NICE guidance (DG7) in 2012 recommended tauroselcholic (75selenium) acid (SeHCAT) for research only for diagnosing bile acid malabsorption (BAM).
- A NICE review of SeHCAT guidance for BAM was scheduled for March 2017.
- BAM, also known as bile acid diarrhoea (BAD), affects patients with IBS-D and Crohn's disease without ileal resection.
Purpose of the Study:
- To summarize recent advances in understanding and diagnosing bile acid malabsorption (BAM).
- To encourage clinicians to reconsider their diagnostic approaches to bile acid diarrhoea (BAD).
- To present evidence supporting the diagnostic utility of tauroselcholic (75selenium) acid scanning.
Main Methods:
- Review of current literature on the prevalence, diagnosis, and treatment of BAD/BAM.
- Analysis of new evidence published since the 2012 NICE review.
- Discussion of the economic impact of misdiagnosing or undertreating BAD/BAM.
Main Results:
- Compelling new evidence demonstrates tauroselcholic (75selenium) acid scanning is effective for diagnosing BAD/BAM.
- Published prevalence data suggests approximately 1% of the UK population may be affected.
- The true prevalence of BAD/BAM may be significantly underestimated.
Conclusions:
- Evidence challenges existing clinical opinions on BAD/BAM.
- Tauroselcholic (75selenium) acid scanning is a valuable diagnostic tool.
- Clinicians and health technology assessment agencies are encouraged to consider new evidence for future assessments.
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