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Updated: Feb 12, 2026

Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
Autologous neurosensory retinal free patch transplantation for persistent full-thickness macular hole
Chiara De Giacinto1, Rossella D'Aloisio2, Gabriella Cirigliano2
1Eye Clinic, Department of Medicine, Surgery and Health Sciences, University of Trieste, Piazza Ospedale 1, 34129, Trieste, Italy. chiaradegiacinto@gmail.com.
Purpose:
To evaluate anatomical and functional outcomes after autologous neurosensory retinal free patch (ANRFP) transplantation for persistent idiopathic full-thickness macular hole (iFTMH).
Methods:
A 65-year-old woman with persistent macular hole in her right eye after previous 27-gauge pars plana vitrectomy with internal limiting membrane peeling and long-acting gas tamponade underwent ANRFP transplantation. Before surgery, best corrected visual acuity in her right eye was 20/800. Optical coherence tomography (OCT) showed a 715-micron-diameter FTMH. To treat the persistent FTMH, a small autologous neurosensory retinal patch was transplanted and placed inside the macular hole under perfluorocarbon liquids (PFCL). PFCL-air exchange was performed, and long-acting gas tamponade was carried out. Clinical features of the macular area, visual acuity (VA), fundus autofluorescence, microperimetry and OCT were recorded during the 10-month follow-up.
Results:
The macular hole appeared successfully closed with retinal patch stable and well plugged into the hole during the whole follow-up. VA improved to 20/100 and microperimetry revealed an increase in mean retinal sensitivity from 14.7 dB at 1 month to 15.6 dB at 10 months postoperatively. OCT showed a well-distinguishable retinal patch into the hole 1 month after surgery and a completely integrated retinal patch between the retinal layers 10 months postoperatively. No intra- and postoperative complications were noticed.
Conclusions:
ANRFP transplantation may represent an innovative technique for persistent iFTMH treatment.
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