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Updated: Feb 12, 2026

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
Published on: June 27, 2025
Tumor-Derived Microparticles to Monitor Colorectal Cancer Evolution
Diane Mege1, Laurence Panicot-Dubois1, Christophe Dubois2
1Aix Marseille University, INSERM UMR-S1076, C2VN, Marseille, France.
Abstract:
Colorectal cancer is the most common gastrointestinal cancer and the second-most common cause of cancer-related death worldwide. Microparticles are small vesicles known to be implicated in tumor growth, the development of metastases, and cancer-associated procoagulant activity. We have reported a specific hallmark of microparticles in colorectal and pancreatic cancers, the so-called "microparticulosome." We have also reported on variations in the microparticulosome in the case of the occurrence of a thromboembolic event. Here, we describe our flow cytometry-based methods for identifying and characterizing tumor-derived microparticles and thereby monitoring colorectal cancer evolution.
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