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Updated: Feb 12, 2026

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
Published on: February 10, 2023
Testing Cell-Based Immunotherapy for Colorectal Cancer
Jong Soon Kang1, Yeo Dae Yoon1, Myeong Youl Lee1
1Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungbuk, Republic of Korea.
Abstract:
Cell-based immunotherapy for cancer is emerging as an attractive alternative to conventional small-molecule or antibody-based treatment. Due to the characteristics of cell-based therapy, validation of test materials before in vivo administration is required. Here we describe general validation steps for preclinical evaluation of cell-based immunotherapy. We also describe a xenograft model of human colorectal cancer. This model can be used for applied to preclinical evaluation of various cell-based therapy regimens for colorectal cancer treatment.
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