Anticoagulation therapy in haemophilia
Hamostaseologie
|March 29, 2018
Summary
Patients with haemophilia (PWH) have reduced cardiovascular death, not from less atherosclerosis, but from protection against occlusive thrombus. Managing anticoagulation in aging PWH requires tailored therapy and risk assessment tools.
Area of Science:
- Cardiology
- Hematology
Background:
- Patients with haemophilia (PWH) exhibit reduced cardiovascular mortality compared to the general population.
- This protection is attributed to reduced occlusive thrombus formation rather than less atherosclerosis.
- The aging haemophilia population necessitates increased attention to cardiovascular events.
Purpose of the Study:
- To review current understanding of cardiovascular disease in PWH.
- To discuss the feasibility and management of anticoagulation in PWH.
- To highlight the need for risk assessment tools and validated management strategies.
Main Methods:
- Literature review and expert opinion on cardiovascular risk and anticoagulation in PWH.
- Discussion of key cardiovascular risk factors: hypertension, overweight, lipometabolic disorders, and smoking.
- Exploration of tailored anticoagulation strategies and monitoring requirements.
Main Results:
- Cardiovascular disease prevalence and incidence data in PWH remain scarce.
- Standard cardiovascular risk factors require screening in PWH.
- Anticoagulation is feasible but demands individualized treatment and close monitoring.
Conclusions:
- Effective anticoagulation management in PWH is achievable with tailored approaches.
- There is an urgent need for validated risk assessment tools and management strategies for PWH.
- Current anticoagulation management in PWH involves navigating unknown factors.
Related Concept Videos
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
2.5K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.5K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
2.0K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.0K
00:59Gene Therapy
27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
01:26Group Therapy
460
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
460
01:22Behavior Therapy
735
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
735
01:28Drug Therapy
304
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
304