Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Facilitated Transport01:19

Facilitated Transport

151.4K
The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a...
151.4K
Facilitated Transport01:19

Facilitated Transport

18.8K
The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a...
18.8K
Social Facilitation01:04

Social Facilitation

36.6K
Not all intergroup interactions lead to negative outcomes. Sometimes, being in a group situation can improve performance. Social facilitation occurs when an individual performs better when an audience is watching than when the individual performs the behavior alone. This typically occurs when people are performing a task for which they are skilled.
36.6K
Encoding01:19

Encoding

875
Information enters the brain through encoding, which is the input of information into the memory system. Once sensory information is received from the environment, the brain labels or codes it. The information is then organized with similar information and connected to existing concepts. Encoding occurs through automatic processing and effortful processing.
Automatic processing involves the encoding of details like time, space, frequency, and the meaning of words, usually done without conscious...
875
Facilitated Diffusion01:16

Facilitated Diffusion

1.3K
The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
1.3K
System of Memory01:23

System of Memory

7.5K
Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multimodal MRI-radiomics deep learning model for survival risk stratification after gamma knife radiosurgery in patients with brain metastases: A multicenter retrospective study.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Decompression with or without Duraplasty for Chiari I and Syringomyelia.

The New England journal of medicine·2026
Same author

Liquid biopsy-based genomic risk score to predict neurologic death in non-small cell lung cancer patients.

Journal of neuro-oncology·2026
Same author

Developing a core outcome set for the NeuroPoint Alliance Quality Outcomes Database Pediatric Tumor Surgery Registry: a modified Delphi study.

Journal of neuro-oncology·2026
Same author

Dietary Pattern-Induced Gut Microbiota Differences Are Associated with White Matter Volume Changes in Middle-Aged Female Macaques.

Nutrients·2026
Same author

Hyaluronan-Based Glioblastoma Tumor Constructs Maintain Patient Tumor Drug Responses and Genomic Parity.

Micromachines·2026

Related Experiment Video

Updated: Feb 12, 2026

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm
06:35

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm

Published on: April 28, 2016

35.5K

Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall.

Robert E Hampson1, Dong Song, Brian S Robinson

  • 1Wake Forest Baptist Medical Center, Winston-Salem, NC, United States of America.

Journal of Neural Engineering
|March 29, 2018
PubMed
Summary

This study shows that using a patient's own neural codes to stimulate the hippocampus can improve memory encoding and retention. This breakthrough offers hope for new treatments for memory loss and the development of memory prosthetics.

More Related Videos

Customizing a Cryolite Glass Prosthetic Eye
08:04

Customizing a Cryolite Glass Prosthetic Eye

Published on: October 31, 2019

11.4K
Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

12.6K

Related Experiment Videos

Last Updated: Feb 12, 2026

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm
06:35

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm

Published on: April 28, 2016

35.5K
Customizing a Cryolite Glass Prosthetic Eye
08:04

Customizing a Cryolite Glass Prosthetic Eye

Published on: October 31, 2019

11.4K
Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

12.6K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Cognitive Science

Background:

  • Memory function is often impaired by neurological conditions, drugs, and injuries.
  • Previous memory restoration efforts focused on general brain modulation rather than specific neural codes.
  • The hippocampus plays a crucial role in memory encoding and retrieval.

Purpose of the Study:

  • To demonstrate the first human implementation of a system to restore memory function by facilitating memory encoding.
  • To utilize a patient's own hippocampal spatiotemporal neural codes for memory enhancement.
  • To develop a proof-of-concept for an implantable neural prosthetic to improve human memory.

Main Methods:

  • A nonlinear multi-input, multi-output (MIMO) model of hippocampal CA3 and CA1 neural firing was developed.
  • The MIMO model predicted neural activation patterns during a short-term memory task (delayed match-to-sample).
  • Electrical stimulation, guided by the MIMO model, was applied to hippocampal CA1 locations during memory encoding.

Main Results:

  • Stimulated trials showed a 37% facilitation in short-term/working memory during the task.
  • A 35% significant improvement in both short-term and long-term visual information retention was observed.
  • The study successfully demonstrated enhanced memory encoding and retention in human subjects.

Conclusions:

  • The findings validate the facilitation of memory encoding as a key target for memory improvement.
  • This research paves the way for the development of advanced neural prosthetics for memory enhancement.
  • The personalized approach using individual neural codes shows promise for effective memory restoration.