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Anemia Associated with Worse Outcome in Diffuse Large B-Cell Lymphoma Patients: A Single-Center Retrospective Study

Kenji Matsumoto1, Shin Fujisawa2, Taiki Ando2

  • 1Yokohama City University Faculty of Medicine, Department of Hematology and Clinical Immunology, Yokohama, Japan

Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology
|March 29, 2018
PubMed

Insights

Anemia, indicated by low hemoglobin (Hb) levels (<10 g/dL), is a significant independent prognostic marker for poor outcomes in diffuse large B-cell lymphoma (DLBCL) patients. This finding aids in risk stratification for DLBCL treatment.

Area of Science:

  • Hematology
  • Oncology
  • Clinical Research

Background:

  • Diffuse large B-cell lymphoma (DLBCL) is a common non-Hodgkin lymphoma.
  • Identifying reliable prognostic biomarkers is crucial for effective patient management and risk stratification.
  • Previous studies have reported various prognostic factors in DLBCL.

Purpose of the Study:

  • To investigate the prognostic value of hemoglobin (Hb) levels in patients diagnosed with DLBCL.
  • To determine if Hb level can serve as an independent prognostic marker for disease outcome.

Main Methods:

  • A retrospective study was conducted on 185 DLBCL patients treated between 2004 and 2014.
  • Patients received standard therapy including rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone.
  • Disease outcome, progression-free survival (PFS), and overall survival were evaluated along with clinical and laboratory factors.

Main Results:

  • Univariate analysis identified factors associated with worse PFS, including ECOG performance status ≥2, Ann Arbor stage III/IV, anemia (Hb <10 g/dL), and low serum albumin (<3.5 g/dL).
  • Multivariate analysis confirmed anemia (Hb <10 g/dL) and Ann Arbor stage III/IV as independent prognostic factors, irrespective of the International Prognostic Index.
  • Anemia showed a hazard ratio of 2.4 (p=0.04) in multivariate analysis.

Conclusions:

  • Anemia, defined by Hb levels below 10 g/dL, is an independent prognostic marker associated with poorer outcomes in DLBCL patients.
  • Hemoglobin level represents an accessible and valuable biomarker for risk stratification in DLBCL patient management.
  • These findings support the integration of Hb level assessment into routine prognostic evaluation for DLBCL.
Abstract

Keywords:
AnemiaDiffuse large B-cell lymphomaHemoglobin

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