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Updated: Feb 12, 2026

In Situ Gas Analysis and Fire Characterization of Lithium-Ion Cells During Thermal Runaway Using an Environmental Chamber
Published on: March 31, 2023
Case for Lithium Tetramethylpiperidide-Mediated Ortholithiations: Reactivity and Mechanisms
1Department of Chemistry and Chemical Biology Baker Laboratory , Cornell University , Ithaca , New York 14853-1301 , United States.
Abstract:
Rate and mechanistic studies of ortholithiations by lithium 2,2,6,6-tetramethylpiperidide focus on four arenes: 1,4-bis(trifluoromethyl)benzene, 1,3-bis(trifluoromethyl)benzene, 1,3-dimethoxybenzene, and 4,4-dimethyl-2-phenyl-2-oxazoline. Metalations occur via substrate-dependent combinations of monosolvated monomer, disolvated monomer, and tetrasolvated dimer (triple ions). Density functional theory computational studies augment the experimental data. We discuss the challenges presented by shifting dimer-monomer proportions in determining the observable reaction orders and our mathematical treatment of such shifting in reactant structure.
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