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Updated: Feb 12, 2026

Determination of the Photoisomerization Quantum Yield of a Hydrazone Photoswitch
Published on: February 7, 2022
Facile Quantum Yield Determination via NMR Actinometry
Yining Ji1, Daniel A DiRocco1, Cynthia M Hong1,2
1Process Research & Development , Merck & Co., Inc. , Rahway , New Jersey 07065 United States.
Abstract:
A simplified approach to quantum yield ([Formula: see text]) measurement using in situ LED NMR spectroscopy has been developed. The utility and performance of NMR actinometry has been demonstrated for the well-known chemical actinometers potassium ferrioxalate and o-nitrobenzaldehyde. A novel NMR-friendly actinometer, 2,4-dinitrobenzaldehyde, has been introduced for both 365 and 440 nm wavelengths. The method has been utilized successfully to measure the quantum yield of several recently published photochemical reactions.
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