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Updated: Feb 12, 2026

Synthesis and Characterization of Supramolecular Colloids
Published on: April 22, 2016
Hydrogen-Bonding-Driven 3D Supramolecular Assembly of Peptidomimetic Zipper
Peng Teng1, Zheng Niu1, Fengyu She1
1Department of Chemistry , University of South Florida , 4202 E. Fowler Avenue , Tampa , Florida 33620 , United States.
Abstract:
Hydrogen-bonding-driven three-dimensional (3D) assembly of a peptidomimetic zipper has been established for the first time by using an α/AApeptide zipper that assembles into a de novo lattice arrangement through two layers of hydrogen-bonded linker-directed interactions. Via a covalently bridged 1D 413-helix, drastic enhancement in stability has been achieved in the formed 3D crystalline supramolecular architecture as evidenced by gas-sorption studies. As the first example of an unnatural peptidic zipper, the dimensional augmentation of the zipper differs from metal-coordinated strategies, and may have general implications for the preparation of peptidic functional materials for a variety of future applications.
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